For research use only. Not for therapeutic Use.
Amorolfine HCl (CAS 78613-38-4) is a 14-alpha demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. In also increases release for prostaglandin D2 metabolites and inhibits production of thymic stromal lymphopoietin in dermatitis models.
| Catalog Number | A000580 |
| CAS Number | 78613-38-4 |
| Synonyms | NA |
| Molecular Formula | C21H36ClNO |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | >6.3mg/mL in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | (2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;hydrochloride |
| InChI | InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+; |
| InChIKey | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
| SMILES | CC(C1=CC=C(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)C=C1)(C)CC.[H]Cl |
| Reference | 1.Hossin B, Rizi K, Murdan S. Application of Hansen Solubility Parameters to predict drug-nail interactions, which can assist the design of nail medicines. Eur J Pharm Biopharm. 2016 May;102:32-40. doi: 10.1016/j.ejpb.2016.02.009. Epub 2016 Feb 23. PubMed PMID: 26924329.<br /> |
