Amoscanate

• CAT Number: I022107
• CAS Number: 26328-53-0
• Molecular Formula: C13H9N3O2S
• Molecular Weight: 271.29
• Purity: ≥95%
• Synonyms: 4-isothiocyanato-N-(4-nitrophenyl)aniline
• InChI: InChI=1S/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H
• InChIKey: DKVNAGXPRSYHLB-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC2=CC=C(C=C2)[N+](=O)[O-])N=C=S

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].
Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1].
Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].
Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].
Amoscanate elicits massive ultrastructural damage in ependymal cells[1].

Reference

[1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212.
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