For research use only. Not for therapeutic Use.
Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens[1].
When activated by light, Amotosalen binds to the nucleic acid of the pathogen and prevents replication. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells[1].
| Catalog Number | I019127 |
| CAS Number | 161262-45-9 |
| Synonyms | 3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one;hydrochloride |
| Molecular Formula | C17H20ClNO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H19NO4.ClH/c1-9-6-15(19)22-16-10(2)17-13(7-12(9)16)14(11(3)21-17)8-20-5-4-18;/h6-7H,4-5,8,18H2,1-3H3;1H |
| InChIKey | MHLAMQBABOJZQW-UHFFFAOYSA-N |
| SMILES | CC1=CC(=O)OC2=C(C3=C(C=C12)C(=C(O3)C)COCCN)C.Cl |
| Reference | [1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8. |
