amphotericin A

• CAT Number: M049980
• CAS Number: 1405-32-9
• Molecular Formula: C48H77NO16
• Molecular Weight: 924.13
• Purity: ≥95%
• Target: Antibiotic
• Storage: -20°C
• IUPAC Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
• InChI: InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChIKey: QGGFZZLFKABGNL-MOISJGEISA-N
• SMILES: CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

Amphotericin A（Cat No.:M049980） is a polyene antifungal antibiotic that is less commonly known compared to its closely related derivative, amphotericin B. This compound is naturally produced by the bacterium Streptomyces nodosus and is effective in treating fungal infections by binding to ergosterol, a key component of fungal cell membranes. By binding to ergosterol, amphotericin A disrupts the cell membrane, leading to cell leakage and death. While it has potent antifungal properties, amphotericin A is primarily of interest for research purposes, with amphotericin B being the preferred choice for clinical applications due to its efficacy.