Amphotericin B

• CAT Number: A000647
• CAS Number: 1397-89-3
• Molecular Formula: C47H73NO17
• Molecular Weight: 924.10
• Purity: ≥95%
• Synonyms: Ambisome; Amphocin; Amfotericina B; Amphotericinum B
• Target: Antibiotic
• Solubility: >46.2mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• InChI: InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChIKey: APKFDSVGJQXUKY-INPOYWNPSA-N
• SMILES: CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

Amphotericin B（Cat No.:A000647）is a potent antifungal medication used to treat severe systemic fungal infections, such as cryptococcal meningitis, aspergillosis, and candidiasis. It works by binding to ergosterol in fungal cell membranes, creating pores that cause cell contents to leak, leading to cell death. Administered intravenously, it is effective against a wide range of fungi. Despite its efficacy, Amphotericin B is known for its significant side effects, including nephrotoxicity, electrolyte imbalances, and infusion-related reactions. Liposomal formulations have been developed to reduce toxicity. Amphotericin B remains a critical option for life-threatening fungal infections.