Amphoteronolide B

• CAT Number: M001683
• CAS Number: 106799-07-9
• Molecular Formula: C41H62O14
• Molecular Weight: 778.93
• Purity: ≥95%
• Synonyms: Amphotericin B aglycone； (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-1,3,5,6,9,11,17,33,37-nonahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• Storage: -20°C
• IUPAC Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,33R,35S,36R,37S)-1,3,5,6,9,11,17,33,37-nonahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• InChI: InChI=1S/C41H62O14/c1-26-16-14-12-10-8-6-4-5-7-9-11-13-15-17-29(42)22-36-38(40(51)52)35(48)25-41(53,55-36)24-32(45)21-34(47)33(46)19-18-30(43)20-31(44)23-37(49)54-28(3)27(2)39(26)50/h4-17,26-36,38-39,42-48,50,53H,18-25H2,1-3H3,(H,51,52)/t26-,27-,28-,29-,30+,31+,32-,33+,34+,35-,36-,38+,39+,41+/m0/s1
• InChIKey: VOPKRGFUUMVSHY-ZQCSYNFZSA-N
• SMILES: CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)O

Amphoteronolide B（Cat No.:M001683） is a macrolide antibiotic that is part of a broader class of bioactive compounds known as polyketides. Derived from natural sources, this compound was first isolated from the bacterium Streptomyces canus. Amphoteronolide B exhibits significant antimicrobial activity, particularly against Gram-positive bacteria. Its structure features a large lactone ring commonly found in macrolides, which is essential for its mechanism of action, typically involving the inhibition of protein synthesis in bacterial cells. The study of amphoteronolide B and similar compounds contributes to the development of new antibiotics to combat resistant bacterial strains.