AMPK activator 2 hydrochloride

• CAT Number: I040336
• Molecular Formula: C13H19ClF3N5
• Molecular Weight: 337.77
• Purity: ≥95%
• Synonyms: (1E)-1-[amino-[4-(trifluoromethyl)anilino]methylidene]-2-(2-methylpropyl)guanidine;hydrochloride
• InChI: InChI=1S/C13H18F3N5.ClH/c1-8(2)7-19-11(17)21-12(18)20-10-5-3-9(4-6-10)13(14,15)16;/h3-6,8H,7H2,1-2H3,(H5,17,18,19,20,21);1H
• InChIKey: XNTYRKPRMWJMAZ-UHFFFAOYSA-N
• SMILES: CC(C)CN=C(N)N=C(N)NC1=CC=C(C=C1)C(F)(F)F.Cl

AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549)[1].

Reference

[1]. Di Xiao, et al. Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives. Bioorg Med Chem. 2020 Jan 15;28(2):115258.
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