Ampkinone

For research use only. Not for therapeutic Use.

  • CAT Number: I000917
  • CAS Number: 1233082-79-5
  • Molecular Formula: C31H23NO6
  • Molecular Weight: 505.52
  • Purity: ≥95%
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Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
Ampkinone stimulates the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake inmuscle cells[1].
Ampkinone-treated DIO mice significantly reduce total body weight and overall fat mass. Histological examination and measurement of lipid parameters show that Ampkinone effectively improves metabolic abnormalities in the DIO mice model[1].


Catalog Number I000917
CAS Number 1233082-79-5
Synonyms

2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethylchromeno[3,4-e]isoindole-1,3-dione

Molecular Formula C31H23NO6
Purity ≥95%
InChI InChI=1S/C31H23NO6/c1-31(2)25-20(21-15-16-23(37-3)27(34)28(21)38-31)13-14-22-24(25)30(36)32(29(22)35)19-11-9-18(10-12-19)26(33)17-7-5-4-6-8-17/h4-16,34H,1-3H3
InChIKey BRRCHDIWBKOMEC-UHFFFAOYSA-N
SMILES CC1(C2=C(C=CC3=C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)C5=CC=CC=C5)C6=C(O1)C(=C(C=C6)OC)O)C
Reference

[1]. Oh S, et al. Antidiabetic and antiobesity effects of Ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase. J Med Chem. 2010 Oct 28;53(20):7405-13.
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