For research use only. Not for therapeutic Use.
Amprolium HCl(Cat No.:A000531)is a hydrochloride salt of amprolium, an effective anticoccidial agent used in veterinary medicine to prevent and treat coccidiosis in poultry and livestock. It acts as a competitive inhibitor of thiamine uptake in Eimeria species, disrupting their carbohydrate metabolism and halting parasite development. Amprolium HCl is commonly administered through feed or water, offering targeted action with minimal impact on the host. Its safety, efficacy, and cost-effectiveness make it an essential component in managing parasitic infections, enhancing animal health, and supporting agricultural productivity.
Catalog Number | A000531 |
CAS Number | 137-88-2 |
Synonyms | NA |
Molecular Formula | C14H19N4.HCl.Cl |
Purity | ≥95% |
Target | Coccidiostat & Thiamine Transporter Inhibitor |
Storage | 3 years -20C powder |
IUPAC Name | 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;chloride;hydrochloride |
InChI | InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1 |
InChIKey | PJBQYZZKGNOKNJ-UHFFFAOYSA-M |
SMILES | CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.Cl.[Cl-] |
Reference | </br>1: el-Sayed MG, Abd el-Aziz MI, el-Kholy MH. Kinetic behaviour of sulphaquinoxaline and amprolium in chickens. Dtsch Tierarztl Wochenschr. 1995 Dec;102(12):481-5. PubMed PMID: 8591749.</br>2: Greenwood J, Pratt OE. Inhibition of thiamine transport across the blood-brain barrier in the rat by a chemical analogue of the vitamin. J Physiol. 1983 Mar;336:479-86. PubMed PMID: 6875915; PubMed Central PMCID: PMC1198979.</br>3: Ernst JV, Lindsay DS, Current WL. Control of Isospora suis-induced coccidiosis on a swine farm. Am J Vet Res. 1985 Mar;46(3):643-5. PubMed PMID: 4039545.</br>4: Molnár K, Ostoros G. Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae). Acta Vet Hung. 2007 Mar;55(1):67-76. PubMed PMID: 17385557.</br></br> |