Amrubicin hydrochloride

• CAT Number: I000424
• CAS Number: 110311-30-3
• Molecular Formula: C25H26ClNO9
• Molecular Weight: 519.93
• Purity: ≥95%
• Target: Topoisomerase II
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
• InChI: InChI=1S/C25H25NO9.ClH/c1-10(27)25(26)7-13-18(16(8-25)35-17-6-14(28)15(29)9-34-17)24(33)20-19(23(13)32)21(30)11-4-2-3-5-12(11)22(20)31;/h2-5,14-17,28-29,32-33H,6-9,26H2,1H3;1H/t14-,15+,16-,17-,25-;/m0./s1
• InChIKey: BHMLHEQFWVQAJS-IITOGVPQSA-N
• SMILES: CC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=CC=CC=C4C3=O)O)OC5CC(C(CO5)O)O)N.Cl

Amrubicin Hydrochloride（Cat No.:I000424）is a potent third-generation anthracycline used in chemotherapy for treating various cancers, including lung cancer. It works by intercalating DNA, inhibiting topoisomerase II, and inducing apoptosis in cancer cells. Amrubicin hydrochloride is particularly effective in treating small cell lung cancer (SCLC) and has shown promise in overcoming resistance to other anthracyclines. Its favorable pharmacokinetic profile and reduced cardiotoxicity compared to earlier anthracyclines make it a valuable option in oncology, offering improved efficacy and safety for cancer patients.