Amsacrine hydrochloride

• CAT Number: I003990
• CAS Number: 54301-15-4
• Molecular Formula: C21H20ClN3O3S
• Molecular Weight: 429.92
• Purity: ≥95%
• Synonyms: N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;hydrochloride
• Target: Autophagy
• Solubility: DMSO:10 mg/mL; 30% Ethanol: 4 mg/mL
• Storage: Store at -20C
• InChI: InChI=1S/C21H19N3O3S.ClH/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21;/h3-13,24H,1-2H3,(H,22,23);1H
• InChIKey: WDISRLXRMMTXEV-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42.Cl

Amsacrine hydrochloride（Cat No.:I003990）is an anthracycline derivative primarily used as a chemotherapeutic agent in the treatment of various hematologic malignancies, including acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It functions by intercalating into DNA and inhibiting topoisomerase II, leading to the disruption of DNA replication and ultimately inducing apoptosis in cancer cells. Amsacrine’s unique mechanism of action enhances its effectiveness against rapidly dividing tumors. Despite its therapeutic benefits, careful monitoring is required due to potential side effects, including cardiotoxicity and myelosuppression, highlighting the importance of managing treatment regimens effectively.

Reference

[1]. Liu WH, et al. Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells. J Cell Physiol. 2013 Oct 7.

[2]. Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94.

[3]. Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33.

[4]. Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68(7-8):989-97.