AMXT-1501

• CAT Number: I022151
• CAS Number: 441022-64-6
• Molecular Formula: C32H68N6O2
• Molecular Weight: 568.92
• Purity: ≥95%
• Synonyms: N-[(5R)-5-amino-6-[3-[4-(3-aminopropylamino)butylamino]propylamino]-6-oxohexyl]hexadecanamide
• InChI: InChI=1S/C32H68N6O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-22-31(39)37-28-16-15-21-30(34)32(40)38-29-20-27-36-25-18-17-24-35-26-19-23-33/h30,35-36H,2-29,33-34H2,1H3,(H,37,39)(H,38,40)/t30-/m1/s1
• InChIKey: USNCWPSRPOWEBG-SSEXGKCCSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)NCCCNCCCCNCCCN)N

AMXT-1501 (Cat No.: I022151) is an investigational small-molecule inhibitor targeting polyamine transport, a crucial pathway for cell growth and proliferation. It is designed to block the uptake of polyamines, which are often elevated in cancer cells, thereby disrupting tumor metabolism and growth. AMXT-1501 is typically studied in combination with difluoromethylornithine (DFMO), which inhibits polyamine synthesis, to achieve dual blockade of the polyamine pathway. This combination shows promise in preclinical and early clinical studies for treating various cancers, including solid tumors and hematologic malignancies.

Reference

[1]. Hayes CS, et al. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar;2(3):274-85.
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