Amyloid beta-peptide(25-35)

• CAT Number: I013434
• CAS Number: 131602-53-4
• Molecular Formula: C₄₅H₈₁N₁₃O₁₄S
• Molecular Weight: 1060.27
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: H2O
• IUPAC Name: 2-[[2-[[2-[[2-[[2-[2-[[2-[[6-amino-2-[[4-amino-2-[[2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoylamino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
• InChI: InChI=1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)
• InChIKey: WIHBNMPFWRHGDF-UHFFFAOYSA-N
• SMILES: CCC(C)C(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)CN

Amyloid beta-peptide (25-35)（Cat No.:I013434）is a truncated fragment of the amyloid beta protein, which is implicated in Alzheimer’s disease. It is commonly used in scientific research as a model to study neurodegenerative processes. The peptide mimics the toxic effects of longer amyloid beta peptides (such as Aβ1-42), which accumulate in the brains of Alzheimer’s patients, forming plaques that disrupt neuronal function. Aβ(25-35) induces neurotoxicity, inflammation, and oxidative stress in cell and animal models, making it a useful tool for understanding Alzheimer’s disease pathogenesis and testing potential therapeutic agents aimed at amyloid plaque reduction.

Reference

[1]. D//’Ursi AM, et al. Solution structure of amyloid beta-peptide (25-35) in different media. J Med Chem. 2004 Aug 12;47(17):4231-8.[2]. Clementi ME, et al. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death throughapoptotic signals: Role of the redox state of methionine-35. FEBS Lett. 2005 May 23;579(13):2913-8.[3]. Liu M, et al. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer//’s disease. BMC Complement Altern Med. 2015 Oct 23;15:382.