For research use only. Not for therapeutic Use.
AN 0128（Cat No.:I002308）is a potent and selective inhibitor of the protein kinase Akt, which plays a crucial role in regulating cell survival, growth, and metabolism. By targeting Akt, AN 0128 is instrumental in modulating the PI3K/Akt signaling pathway, which is often dysregulated in various cancers. This compound is under investigation for its potential therapeutic applications in oncology, particularly in cancers characterized by Akt overactivation. AN 0128 shows promise as an effective agent for inhibiting tumor progression and enhancing the efficacy of existing cancer treatments.
| Catalog Number | I002308 |
| CAS Number | 872044-70-7 |
| Synonyms | AN-0128; CRM-0005; ONT-0001; AN0128; CRM0005; ONT0001; AN 0128; CRM 0005; ONT 0001;((bis(3-chloro-4-methylphenyl)boraneyl)oxy)(3-hydroxypyridin-2-yl)methanone |
| Molecular Formula | C20H16BCl2NO3 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO |
| Storage | 4°C, protect from light |
| IUPAC Name | bis(3-chloro-4-methylphenyl)boranyl 3-hydroxypyridine-2-carboxylate |
| InChI | InChI=1S/C20H16BCl2NO3/c1-12-5-7-14(10-16(12)22)21(15-8-6-13(2)17(23)11-15)27-20(26)19-18(25)4-3-9-24-19/h3-11,25H,1-2H3 |
| InChIKey | ZTLSOLUCMQEGEA-UHFFFAOYSA-N |
| SMILES | B(C1=CC(=C(C=C1)C)Cl)(C2=CC(=C(C=C2)C)Cl)OC(=O)C3=C(C=CC=N3)O |
| Reference | </br>1:Biological evaluation of RBx-0128, a potent and selective dipeptidyl peptidase-IV inhibitor in type 2 diabetes genetic model. Davis JA, Kumar PS, Singh S, Surender A, Roy S, Khanna V, Sethi S, Pal C, Sharma L, Benjamin B, Mittra S, Sattigeri J, Bansal VS.Indian J Pharmacol. 2012 Nov-Dec;44(6):759-64. doi: 10.4103/0253-7613.103298. PMID: 23248408 Free PMC Article</br>2:Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128. Weidhaas JB, Li SX, Winter K, Ryu J, Jhingran A, Miller B, Dicker AP, Gaffney D.Clin Cancer Res. 2009 Jun 15;15(12):4199-206. doi: 10.1158/1078-0432.CCR-08-2257. Epub 2009 Jun 9. PMID: 19509178 Free PMC Article</br>3:Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Zempolich K, Fuhrman C, Milash B, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC, Gaffney DK.Gynecol Oncol. 2008 May;109(2):275-9. doi: 10.1016/j.ygyno.2008.01.027. Epub 2008 Mar 4. PMID: 18299147 </br>4:A Phase II study of acute toxicity for Celebrex (celecoxib) and chemoradiation in patients with locally advanced cervical cancer: primary endpoint analysis of RTOG 0128. Gaffney DK, Winter K, Dicker AP, Miller B, Eifel PJ, Ryu J, Avizonis V, Fromm M, Greven K.Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):104-9. Epub 2006 Nov 2. PMID: 17084549 </br>5:Feasibility of RNA collection for micro-array gene expression analysis in the treatment of cervical carcinoma: a scientific correlate of RTOG C-0128. Gaffney DK, Winter K, Fuhrman C, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC, Zempolich K.Gynecol Oncol. 2005 May;97(2):607-11. PMID: 15863167 </br>6:MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice. Fujita F, Koike M, Fujita M, Sakamoto Y, Okuno S, Kawaguchi T, Yano S, Yano T, Kiuchi S, Fujiwara T, Kudoh S, Kakushima M.Clin Cancer Res. 2005 Feb 15;11(4):1650-7. PMID: 15746070 Free Article</br>7:Characterization of colonization factor antigen CFA/I from an enterotoxigenic Escherichia coli strain (0128:H12). Dima VF, Petrovici A, Dima SV.Arch Roum Pathol Exp Microbiol. 1990 Oct-Dec;49(4):297-313. PMID: 1983732 </br>8:[Identification of serological group 0128:K67 Escherichia]. Kiseleva BS, Gedze GI, Drobyshevskaia EI, Chuprun RM, Kireeva LM.Zh Mikrobiol Epidemiol Immunobiol. 1976 Jun;(6):70-3. Russian. PMID: 948960 |
