For research use only. Not for therapeutic Use.
AN-2898(CAT: I002327) is a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection. AN2898 inhibited phosphodiesterase 4 (PDE4) enzyme activity (IC50 0.060 μM) and the release of multiple cytokines including TNF-α (IC50 0.16 μM) from peripheral blood mononuclear cells (hPBMCs) stimulated by lipopolysaccharide (LPS) or phytohemag- glutinin.
| Catalog Number | I002327 |
| CAS Number | 906673-33-4 |
| Synonyms | AN-2898; AN 2898; AN2898.;4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile |
| Molecular Formula | C15H9BN2O3 |
| Purity | ≥95% |
| Target | PDE4 inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months). |
| IUPAC Name | 4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzene-1,2-dicarbonitrile |
| InChI | InChI=1S/C15H9BN2O3/c17-7-10-1-2-13(5-11(10)8-18)21-14-3-4-15-12(6-14)9-20-16(15)19/h1-6,19H,9H2 |
| InChIKey | UBMGTTRDNUKZMT-UHFFFAOYSA-N |
| SMILES | B1(C2=C(CO1)C=C(C=C2)OC3=CC(=C(C=C3)C#N)C#N)O |
| Reference | </br>1: Ciaravino V, Plattner J, Chanda S. An assessment of the genetic toxicology of </br> novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013</br> Jun;54(5):338-46. doi: 10.1002/em.21779. Epub 2013 Apr 26. PubMed PMID: 23625818.</br></br> |
