For research use only. Not for therapeutic Use.
AN3661（Cat No.:I015529）is a potent antimalarial lead compound that targets the cleavage and polyadenylation specificity factor homolog subunit 3 (PfCPSF3) of Plasmodium falciparum, the parasite responsible for the most severe form of malaria in humans. AN3661 has shown strong inhibitory activity against laboratory-adapted strains of Plasmodium falciparum, Ugandan field isolates, and mice P. berghei and P. falciparum, with average IC50 values of 32nM and 64nM, respectively. AN3661 represents a promising candidate for the development of new antimalarial drugs.
| Catalog Number | I015529 |
| CAS Number | 1268335-33-6 |
| Molecular Formula | C₁₀H₁₁BO₄ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 3-(1-hydroxy-3H-2,1-benzoxaborol-7-yl)propanoic acid |
| InChI | InChI=1S/C10H11BO4/c12-9(13)5-4-7-2-1-3-8-6-15-11(14)10(7)8/h1-3,14H,4-6H2,(H,12,13) |
| InChIKey | CEVOKIPNIZQANN-UHFFFAOYSA-N |
| SMILES | B1(C2=C(CO1)C=CC=C2CCC(=O)O)O |
| Reference | [1]. Sonoiki E, et al. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun. 2017;8:14574. Published 2017 Mar 6. |
