Anagrelide hydrochloride

• CAT Number: I004189
• CAS Number: 58579-51-4
• Molecular Formula: C10H8Cl3N3O
• Molecular Weight: 292.55
• Purity: ≥95%
• Synonyms: 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one;hydrochloride
• Target: PDE
• Solubility: DMSO 14 mg/mL; Water <1 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one;hydrochloride
• InChI: InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H
• InChIKey: TVWRQCIPWUCNMI-UHFFFAOYSA-N
• SMILES: C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl

Anagrelide hydrochloride（Cat No.:I004189）is a medication primarily used to treat essential thrombocythemia, a condition characterized by abnormally high platelet counts, which increases the risk of blood clots. It works by selectively inhibiting megakaryocyte maturation, thereby reducing platelet production in the bone marrow. Anagrelide hydrochloride helps lower the risk of clotting complications like stroke or heart attack in patients with high platelet counts. Its targeted action on megakaryocytes makes it valuable in hematology research, and it is widely prescribed for managing chronic myeloproliferative disorders to maintain safe platelet levels.

Reference

[1]. Pescatore, S.L. and C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.
[2]. Petrides, P.E., Anagrelide: what was new in 2004 and 2005? Semin Thromb Hemost, 2006. 32(4 Pt 2): p. 399-408.