Anastrozole

• CAT Number: A000973
• CAS Number: 120511-73-1
• Molecular Formula: C17H19N5
• Molecular Weight: 293.4
• Purity: ≥95%
• Synonyms: 120511-73-1; Arimidex; Anastrazole; Anastrozol; ZD1033
• Target: Cytochrome P450
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 15 nM
• IUPAC Name: 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
• InChI: InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
• InChIKey: YBBLVLTVTVSKRW-UHFFFAOYSA-N
• SMILES: CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N

Anastrozole (CAS 120511-73-1), sold under the trade name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.

Common side effects include hot flashes, altered mood, joint pain, and nausea. Severe side effects include an increased risk of heart disease and osteoporosis. Use during pregnancy is known to harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the creation of estrogen.

Reference

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