For research use only. Not for therapeutic Use.
Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Item No. <span class=/itemid/>11764</span> in multidrug resistant VJ-300 cell culture (the IC<sub>50</sub> of vincristine decreased 1.5-20-fold upon treatment with 6.25 μg/ml to 50 μg/ml of of andrastin A), most likely by binding to plasma membrane phosphoglycoprotein to prevent drug efflux. Andrastin A inhibits survival of Caco-2 cells with an IC<sub>50</sub> of >50 μg/ml.
| Catalog Number | R067089 |
| CAS Number | 174232-42-9 |
| Synonyms | NSC 697452 |
| Molecular Formula | C₂₈H₃₈O₇ |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18?,19-,20?,25?,26+,27+,28?/m0/s1 |
| InChIKey | GRBXNADBNJGZRK-BCMOVVIDSA-N |
| SMILES | CC1C(=O)C2(C(=CC3C(C2(C1=O)C(=O)OC)(CCC4C3(CCC(C4(C)C)OC(=O)C)C=O)C)C)C |
| Reference | 1.Uchida, R.,Shiomi, K.,Inokosho, J., et al. Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis. J. Antibiot. (Tokyo) 49(5), 418-424 (1996). |
