For research use only. Not for therapeutic Use.
Angiotensin 1-7 (Cat No.:I003877) is a peptide hormone involved in blood pressure regulation. Derived from angiotensin I, it acts as a vasodilator, widening blood vessels and reducing blood pressure. It counteracts the vasoconstrictive effects of Angiotensin II. Angiotensin 1-7 also possesses anti-inflammatory and anti-fibrotic properties and regulates cardiac function, fluid balance, and electrolyte balance.
| Catalog Number | I003877 |
| CAS Number | 51833-78-4 |
| Molecular Formula | C41H62N12O11 |
| Purity | ≥95% |
| Target | Angiotensin Receptor; Angiotensin-converting Enzyme (ACE); Endogenous Metabolite |
| Solubility | H2O: ≥ 30.2 mg/mL |
| Storage | −20°C |
| IUPAC Name | (2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid |
| InChI | InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1 |
| InChIKey | PVHLMTREZMEJCG-GDTLVBQBSA-N |
| SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N |
| Reference | </br>1:Reduced anxiety-like behavior in transgenic rats which chronically overexpress angiotensin-(1-7): Role of the Mas receptor. Kangussu LM, Almeida-Santos AF, Moreira FA, Fontes MAP, Santos RAS, Aguiar DC, Campagnole-Santos MJ.Behav Brain Res. 2017 May 11. pii: S0166-4328(17)30521-1. doi: 10.1016/j.bbr.2017.05.026. [Epub ahead of print] PMID: 28502733 </br>2:THE EFFECTS OF ANGIOTENSIN-(1-7) ON THE NHE3 EXCHANGER AND ON [Ca2+]i IN THE PROXIMAL TUBULES OF SPONTANEOUSLY HYPERTENSIVE RATS. Castelo-Branco R, Leite-Dellova DCA, Fernandes F, Malnic G, Mello-Aires M.Am J Physiol Renal Physiol. 2017 May 10:ajprenal.00557.2016. doi: 10.1152/ajprenal.00557.2016. [Epub ahead of print] PMID: 28490531 </br>3:Anti-inflammatory action of angiotensin 1-7 in experimental colitis may be mediated through modulation of serum cytokines/chemokines and immune cell functions. Khajah MA, Fateel MM, Ananthalakshmi KV, Luqmani YA.Dev Comp Immunol. 2017 May 6;74:200-208. doi: 10.1016/j.dci.2017.05.005. [Epub ahead of print] PMID: 28487234 </br>4:Reduced sympathetic stimulus and angiotensin 1-7 are related to diastolic dysfunction in spinal cord injured subjects. Schreiber R, Paim LR, de Rossi G, Matos-Souza JR, Costa E Silva A, Nogueira CD, Azevedo ER, Alonso KC, Palomino Z, Sposito AC, Casarini DE, Gorla JI, Cliquet A, Nadruz W.J Neurotrauma. 2017 May 2. doi: 10.1089/neu.2016.4902. [Epub ahead of print] PMID: 28463644 </br>5:Long-term effects of angiotensin-(1-7) on lipid metabolism in the adipose tissue and liver. Moreira CCL, Lourenço FC, Mario ÉG, Santos RAS, Botion LM, Chaves VE.Peptides. 2017 Jun;92:16-22. doi: 10.1016/j.peptides.2017.04.004. Epub 2017 Apr 22. PMID: 28438644 </br>6:Angiotensin-(1-7) attenuates angiotensin II-induced cardiac hypertrophy via a Sirt3-dependent mechanism. Guo L, Yin A, Zhang Q, Zhong T, O/’Rourke ST, Sun C.Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H980-H991. doi: 10.1152/ajpheart.00768.2016. Epub 2017 Apr 14. PMID: 28411231 </br>7:Angiotensin-(1-7) in human follicular fluid correlates with oocyte maturation. Cavallo IK, Dela Cruz C, Oliveira ML, Del Puerto HL, Dias JA, Lobach VN, Casalechi M, Camargos MG, Reis AM, Santos RA, Reis FM.Hum Reprod. 2017 Jun 1;32(6):1318-1324. doi: 10.1093/humrep/dex072. PMID: 28402544 </br>8:The complex of PAMAM-OH dendrimer with Angiotensin (1-7) prevented the disuse-induced skeletal muscle atrophy in mice. Márquez-Miranda V, Abrigo J, Rivera JC, Araya-Durán I, Aravena J, Simon F, Pacheco N, González-Nilo FD, Cabello-Verrugio C.Int J Nanomedicine. 2017 Mar 13;12:1985-1999. doi: 10.2147/IJN.S125521. eCollection 2017. PMID: 28331320 Free PMC Article</br>9:[Effects and related mechanism of angiotensin-(1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells]. Yan WF, Xue JJ, Yang HY, Liang B, Yang ZM.Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Mar 24;45(3):223-229. doi: 10.3760/cma.j.issn.0253-3758.2017.03.010. Chinese. PMID: 28316179 </br>10:Angiotensin-(1-7) Downregulates Diabetes-Induced cGMP Phosphodiesterase Activation in Rat Corpus Cavernosum. Dhaunsi GS, Yousif M, Makki B, Akhtar S, Benter IF.Biomed Res Int. 2017;2017:5084961. doi: 10.1155/2017/5084961. Epub 2017 Feb 19. PMID: 28299329 Free PMC Article |
