For research use only. Not for therapeutic Use.
Angiotensin II (human)（Cat No.:I003582）is a potent vasoconstrictor peptide hormone that plays a critical role in regulating blood pressure and fluid balance. It acts on the angiotensin receptors, primarily AT1, to constrict blood vessels, increase aldosterone secretion, and enhance sodium and water retention, ultimately raising blood pressure. Angiotensin II is a key component of the renin-angiotensin-aldosterone system (RAAS) and is central to the management of conditions such as hypertension, heart failure, and kidney disorders. It is widely studied in research focused on cardiovascular and renal health therapies.
| Catalog Number | I003582 |
| CAS Number | 4474-91-3 |
| Synonyms | 5-L-isoleucine-angiotensin II |
| Molecular Formula | C50H71N13O12 |
| Purity | ≥95% |
| Target | Angiotensin receptor |
| Solubility | 10 mM in water |
| Storage | Store at -20°C |
| IUPAC Name | (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid |
| InChI | InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 |
| InChIKey | CZGUSIXMZVURDU-JZXHSEFVSA-N |
| SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N |
| Reference | </br>1:[A case of intrahepatic infusion chemotherapy with angiotensin II human for liver metastasis from early gastric cancer]. Iwasaki Y, Kitamura M, Arai K.Gan To Kagaku Ryoho. 1995 Sep;22(11):1674-8. Japanese. PMID: 7574790 </br>2:[The effect of induced hypertension chemotherapy using angiotensin II human in patients with advanced gastric carcinoma–a histopathological evaluation on the excised stomachs]. Nakamura M, Takahashi T, Sato H, Wakui A, Hoshi M.Gan To Kagaku Ryoho. 1991 Apr;18(4):563-9. Japanese. PMID: 2012398 </br>3:[Randomized controlled trial of induced hypertension chemotherapy (IHC) using angiotensin II human (TY-10721) in advanced gastric carcinoma (TY-10721 IHC Study Group Report)]. Sato H, Wakui A, Hoshi M, Kurihara M, Yokoyama M, Shimizu H.Gan To Kagaku Ryoho. 1991 Mar;18(3):451-60. Japanese. PMID: 1900686 |
