Anidulafungin (LY303366)

• CAT Number: A000141
• CAS Number: 166663-25-8
• Molecular Formula: C58H73N7O17
• Molecular Weight: 1140.30
• Purity: ≥95%
• Target: Antibiotic
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20C
• IUPAC Name: N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-4-[4-(4-pentoxyphenyl)phenyl]benzamide
• InChI: InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1
• InChIKey: JHVAMHSQVVQIOT-MFAJLEFUSA-N
• SMILES: CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N[C@H]4C[C@H]([C@H](NC(=O)[C@@H]5[C@H]([C@H](CN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC4=O)[C@@H](C)O)O)[C@@H]([C@H](C7=CC=C(C=C7)O)O)O)[C@@H](C)O)C)O)O)O

Anidulafungin (LY303366)（Cat No.:A000141）is an echinocandin antifungal agent used in pharmaceutical research and clinical applications. It inhibits 1,3-β-D-glucan synthase, an essential enzyme for fungal cell wall synthesis, leading to cell lysis and death. Effective against Candida and Aspergillus species, Anidulafungin is particularly valued for treating invasive fungal infections, especially in immunocompromised patients. Its unique mechanism of action and low risk of resistance make it a critical focus in antifungal drug development. Research also explores its pharmacokinetics and combination therapies for enhanced antifungal efficacy.

Reference

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