For research use only. Not for therapeutic Use.
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2].
Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone[2].
Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR[2].
Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%[2].
| Catalog Number | I018258 |
| CAS Number | 55449-49-5 |
| Synonyms | [(1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate;hydrobromide |
| Molecular Formula | C17H24BrNO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H23NO4.BrH/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11;/h2-6,12-16,19-20H,7-10H2,1H3;1H/t12-,13-,14+,15+,16-;/m0./s1 |
| InChIKey | KMYQCELRVANQNG-YXGOVGSCSA-N |
| SMILES | CN1C2CC(CC1C(C2)O)OC(=O)C(CO)C3=CC=CC=C3.Br |
| Reference | [1]. Eisenkraft A. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016;173(11):1719-1727. [2]. Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641. |
