For research use only. Not for therapeutic Use.
Anisomycin（Cat No.:I002743）is an antibiotic and potent inhibitor of protein synthesis, primarily used in research to study cell signaling and apoptosis. It acts by binding to the 60S ribosomal subunit and inhibiting protein elongation during translation. This halts protein synthesis, leading to cell stress and apoptosis. Anisomycin is also known to activate stress-activated protein kinases (SAPKs), such as JNK and p38, which are involved in the cellular response to stress. Due to its ability to induce apoptosis, it has been used in cancer research and to explore mechanisms of cellular stress and inflammatory responses.
| Catalog Number | I002743 |
| CAS Number | 22862-76-6 |
| Synonyms | Anisomycin; (2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate |
| Molecular Formula | C₁₄H₁₉NO₄ |
| Purity | ≥95% |
| Target | MAPK/ERK Pathway |
| Solubility | 10 mM in DMSO |
| Storage | Desiccate at +4°C |
| IUPAC Name | [(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate |
| InChI | InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 |
| InChIKey | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
| SMILES | CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O |
| Reference | 1: GONZALEZ CONSTANDSE R. [Anisomycin in intestinal amebiasis; study of 30 <br> 3: LYNCH JE, HOLLEY EC, SALMIRS AM. Effect of anisomycin on the growth of 4: LYNCH JE, ENGLISH AR, MORRISON J, MAVEN I. Protective action of anisomycin in 5: LYNCH JE, ENGLISH AR, BAUCK H, DELIGIANIS H. Studies on the in vitro activity |
