Anlotinib (AL3818) dihydrochloride

• CAT Number: I001960
• CAS Number: 1360460-82-7
• Molecular Formula: C23H22FN3O3.2HCl
• Molecular Weight: 480.36
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1=CC2=C(N1)C=CC(=C2F)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC.Cl.Cl

Anlotinib (AL3818) is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. It has broad-spectrum antitumor potential in clinical trials. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.

Reference

[1] Xie C, et al. Cancer Sci. 2018, 109(4):1207-1219.
[2] Sun Y, et al. J Hematol Oncol. 2016, 9(1):105.
[3] Zhong CC, et al. Acta Pharmacol Sin. 2018, 39(6):1048-1063.