Annamycin

For research use only. Not for therapeutic Use.

  • CAT Number: I002386
  • CAS Number: 92689-49-1
  • Molecular Formula: C26H25IO11
  • Molecular Weight: 640.379
  • Purity: ≥95%
Inquiry Now

Annamycin liposomal is a liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including P-glycoprotein (P-gp). Liposomal annamycin is less toxic and shows improved antitumor activity compared to annamycin.


Catalog Number I002386
CAS Number 92689-49-1
Synonyms

Annamycin.;(7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione

Molecular Formula C26H25IO11
Purity ≥95%
Target Type II DNA topoisomerase
Solubility Soluble in DMSO, not in water
Storage 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
Overview of Clinical Research

Originator: University of Texas M. D. Anderson Cancer Center<br />
Developer: Aronex Pharmaceuticals; Callisto Pharmaceuticals; Moleculin Biotech; University of Texas M. D. Anderson Cancer Center<br />
Class: Anthracyclines: Antineoplastics; Cytostatic antibiotics<br />
Mechanism of Action: Type II DNA topoisomerase inhibitors<br />
Orphan Drug Status: Yes – Acute lymphoblastic leukaemia; Acute myeloid leukaemia<br />

IUPAC Name (7S,9S)-7-[(2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione
InChI InChI=1S/C26H25IO11/c1-9-19(30)24(35)18(27)25(37-9)38-13-7-26(36,14(29)8-28)6-12-15(13)23(34)17-16(22(12)33)20(31)10-4-2-3-5-11(10)21(17)32/h2-5,9,13,18-19,24-25,28,30,33-36H,6-8H2,1H3/t9-,13-,18+,19-,24-,25-,26-/m0/s1
InChIKey CIDNKDMVSINJCG-GKXONYSUSA-N
SMILES CC1C(C(C(C(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)CO)O)I)O)O

Request a Quote