Ansamitocin P-3

• CAT Number: I004503
• CAS Number: 66584-72-3
• Molecular Formula: C32H43ClN2O9
• Molecular Weight: 635.14
• Purity: ≥95%
• Target: Microtubule; ADCs cytotoxin
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IC50: 0.015 ng/ml (Antiproliferative activity for primary human endothel cells)
• IUPAC Name: [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate
• InChI: InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1
• InChIKey: OPQNCARIZFLNLF-JBHFWYGFSA-N
• SMILES: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O

Ansamitocin P-3（Cat No.:I004503）is a potent antitumor agent derived from the bacterium Nocardia species. It belongs to the class of maytansinoids, which are known for their ability to inhibit microtubule dynamics, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. Ansamitocin P-3 has demonstrated significant cytotoxicity against various cancer cell lines and is being investigated for its potential in targeted therapies, particularly in antibody-drug conjugates (ADCs). Its ability to disrupt microtubule function makes it a valuable candidate in the development of innovative cancer treatments aimed at improving efficacy and reducing systemic toxicity.

Reference

[1]. Axel Meyer, et al. Chemoenzymatic Approaches toward Dechloroansamitocin P-3. Org. Lett., 2007, 9 (8), pp 1489-1492.
[2]. Liu Z, et al. An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics. J Pharm Biomed Anal. 2004 Nov 19;36(4):815-21.
[3]. Suwanborirux K, et al. Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes. Experientia. 1990 Jan 15;46(1):117-20.
[4]. Liu Z, et al. Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. J Mass Spectrom. 2005 Mar;40(3):389-99.