Ansatrienin B

• CAT Number: R003877
• CAS Number: 82189-04-6
• Molecular Formula: C36H50N2O8
• Molecular Weight: 638.80
• Purity: ≥95%
• Synonyms: Mycotrienin II;SDZ-115 962
• Target: Antibiotic
• Storage: -20°C
• IUPAC Name: (15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(23),6,8,10,16,20(24),21-heptaen-13-yl) 2-(cyclohexanecarbonylamino)propanoate
• InChI: InChI=1S/C36H50N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,39,41-42H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)
• InChIKey: VVJDHJZQBGWPEQ-UHFFFAOYSA-N
• SMILES: CC1C(CC=CC=CC=CC(CC(=O)NC2=CC(=CC(=C2O)CCC=C(C1O)C)O)OC)OC(=O)C(C)NC(=O)C3CCCCC3

Ansatrienin B（Cat No.:R003877）is a high-purity ansamycin antibiotic derived from microbial sources, widely utilized in pharmacological and biochemical research. It exhibits potent anticancer and antifungal activities by targeting protein biosynthesis and cellular energy metabolism. Ansatrienin B specifically inhibits mitochondrial function by disrupting ATP synthesis, making it a valuable tool for studying energy-dependent cellular processes. Its unique mechanism of action and bioactivity provide insights into therapeutic strategies for cancer and fungal infections. High purity ensures reliable results in experimental and preclinical research settings, advancing drug discovery and natural product studies.

Reference

1.Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption. Feuerbach D. et al. , J. Biol. Chem. 1995, 270, 25949. 

2.Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluoro-uracil by mycotrienins and mycotrienols. Kuwano M. et al. , Gann. 1983, 74, 759. 

3.Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II. Sugita M. et al. , J. Antibiot. 1982, 35, 1467.