Ansofaxine hydrochloride

• CAT Number: I013375
• CAS Number: 916918-84-8
• Molecular Formula: C₂₄H₃₂ClNO₃
• Molecular Weight: 417.97
• Purity: ≥95%
• Target: 5-HT Receptor; Dopamine Receptor
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: [4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenyl] 4-methylbenzoate;hydrochloride
• InChI: InChI=1S/C24H31NO3.ClH/c1-18-7-9-20(10-8-18)23(26)28-21-13-11-19(12-14-21)22(17-25(2)3)24(27)15-5-4-6-16-24;/h7-14,22,27H,4-6,15-17H2,1-3H3;1H
• InChIKey: BVWFJKQJRNSYCR-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C(CN(C)C)C3(CCCCC3)O.Cl

Ansofaxine hydrochloride (Cat No.:I013375) is a compound that acts as a triple reuptake inhibitor. It inhibits the reuptake of serotonin, dopamine, and norepinephrine, three important neurotransmitters involved in mood regulation and neurotransmission. Ansofaxine hydrochloride exhibits moderate potency in inhibiting the reuptake of these neurotransmitters, with IC50 values of 723 nM for serotonin, 491 nM for dopamine, and 763 nM for norepinephrine. This triple reuptake inhibition mechanism may contribute to its potential therapeutic effects in conditions such as depression and other mood disorders.

Reference

[1]. Zhang R, et al. The effects of LPM570065, a novel triple reuptake inhibitor, on extracellular serotonin, dopamineand norepinephrine levels in rats. PLoS One. 2014 Mar 10;9(3):e91775.