ANT431

• CAT Number: I022221
• CAS Number: 1639972-90-9
• Molecular Formula: C9H7N3O4S2
• Molecular Weight: 285.292
• Purity: 98%
• Synonyms: ANT431; ANT 431; ANT-431
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-(Pyridine-3-sulfonamido)thiazole-4-carboxylic acid
• InChI: InChI=1S/C9H7N3O4S2/c13-9(14)7-8(17-5-11-7)12-18(15,16)6-2-1-3-10-4-6/h1-5,12H,(H,13,14)
• InChIKey: OLGRJQGVXXCIMN-UHFFFAOYSA-N
• SMILES: O=C(C1=C(NS(=O)(C2=CC=CN=C2)=O)SC=N1)O

ANT431 is a novel metallo-β-lactamase inhibitor for the treatment of carbapenem-resistant enterobacteriaceae infections

Reference

1: Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT. SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model. ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30. PubMed PMID: 30427656; PubMed Central PMCID: PMC6332448.
2: Everett M, Sprynski N, Coelho A, Castandet J, Bayet M, Bougnon J, Lozano C, Davies DT, Leiris S, Zalacain M, Morrissey I, Magnet S, Holden K, Warn P, De Luca F, Docquier JD, Lemonnier M. Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00074-18. doi: 10.1128/AAC.00074-18. Print 2018 May. PubMed PMID: 29530861; PubMed Central PMCID: PMC5923143.