Anti-inflammatory agent 36

• CAT Number: I041773
• CAS Number: 2293951-01-4
• Molecular Formula: C25H27NO7
• Molecular Weight: 453.48
• Purity: ≥95%
• Synonyms: (3E)-1-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]-3-[(3,4,5-trimethoxyphenyl)methylidene]piperidin-2-one
• InChI: InChI=1S/C25H27NO7/c1-30-20-13-16(7-9-19(20)27)8-10-23(28)26-11-5-6-18(25(26)29)12-17-14-21(31-2)24(33-4)22(15-17)32-3/h7-10,12-15,27H,5-6,11H2,1-4H3/b10-8+,18-12+
• InChIKey: XQUXWWVMQPNGGF-KWKAUDIHSA-N
• SMILES: COC1=CC(=CC(=C1OC)OC)C=C2CCCN(C2=O)C(=O)C=CC3=CC(=C(C=C3)O)OC

Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation[1].
Anti-inflammatory agent 36 (Compound 5a28) (2.5-20 μM) inhibits LPS-induced release of TNF-α and IL-6 in active RAW 264.7 mouse macrophages, with IC50s of 3.69 and 3.68 µM for TNF-α and IL-6[1].
Anti-inflammatory agent 36 (10 μM, 0.5 h) inhibits LPS-induced P-P38 and P-ERK in RAW 264.7 mouse macrophages[1].
Anti-inflammatory agent 36 (10 μM, 0.5 h) inhibits LPS-induced the transcription of TNF-α, IL-6, IL-1β, ICAM-1 and VCAM-1[1].
Anti-inflammatory agent 36 (Compound 5a28) (10 mg/kg, i.p.) inhibits inflammation in acute lung injury mouse model[1].

Reference

[1]. Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425.
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