For research use only. Not for therapeutic Use.
Anti-inflammatory agent 49 (CAT: I040882) is a potent and selective inhibitor of the Drp1-Fis1 interaction, with an IC50 of 270 nM for inhibiting GTPase activity in vitro. By blocking this interaction, SC9 can reduce FIS1-mediated mitochondrial dysfunction, which plays a key role in inflammatory and degenerative diseases. SC9 has potential applications in research related to mitochondrial dynamics, neuroinflammation, and conditions such as neurodegenerative diseases where mitochondrial dysfunction contributes to disease progression. It offers a promising avenue for targeting mitochondrial fission in therapeutic strategies.
| CAS Number | 851471-44-8 |
| Synonyms | N-(6-amino-1-benzyl-2,4-dioxopyrimidin-5-yl)-2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-methylacetamide |
| Molecular Formula | C21H22N8O3S |
| Purity | ≥95% |
| IUPAC Name | N-(6-amino-1-benzyl-2,4-dioxopyrimidin-5-yl)-2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-methylacetamide |
| InChI | InChI=1S/C21H22N8O3S/c1-12-9-13(2)29-19(23-12)25-20(26-29)33-11-15(30)27(3)16-17(22)28(21(32)24-18(16)31)10-14-7-5-4-6-8-14/h4-9H,10-11,22H2,1-3H3,(H,24,31,32) |
| InChIKey | JHYOSGNTLVJJKT-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NC2=NC(=NN12)SCC(=O)N(C)C3=C(N(C(=O)NC3=O)CC4=CC=CC=C4)N)C |
