Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

• CAT Number: I042787
• Purity: ≥95%

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3)[1][2].
Anti-Mouse IFNAR1 Antibody (MAR1-5A3) (20 μg/ml, 18 h) inhibits IFNAR1 signaling in Bone marrow-derived macrophages[2].
Anti-Mouse IFNAR1 Antibody (MAR1-5A3) (250-500 μg/mouse for i.p.) inhibits IFNAR1 signaling in WT mice model[1].

Reference

[1]. Macal M, et al. Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection. Immunity. 2018 Apr 17;48(4):730-744.e5.
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[2]. Schliehe C, et al. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol. 2015 Jan;16(1):67-74.
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