Anti-SARS-CoV-2 Spike mAb (CR3022)

• CAT Number: I044221
• Purity: ≥95%

Anti-SARS-CoV-2 Spike mAb (CR3022) is a a CHO cell derived human monoclonal IgG1 antibody. It binds to both S1 domain of SARS-CoV/SARS-CoV-2 Spike protein[1][2].
CR3022 recognizes a cryptic epitope that is only accessible when S protein is in “open” conformations[1].
CR3022 binds more tightly to SARS-CoV because its epitope contains a glycan not present in SARS-CoV-2[2].

Reference

[1]. Yanling Wu, et al. Identification of Human Single-Domain Antibodies Against SARS-CoV-2. Cell Host Microbe. 2020 Jun 10;27(6):891-898.e5.
 [Content Brief]

[2]. Meng Yuan, et al. A Highly Conserved Cryptic Epitope in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV. Science. 2020 May 8;368(6491):630-633.
 [Content Brief]