Antibacterial agent 131

• CAT Number: I042055
• Molecular Formula: C24H17ClN4OS
• Molecular Weight: 444.94
• Purity: ≥95%
• Synonyms: N-[(E)-(2-chloro-6-methoxyquinolin-3-yl)methylideneamino]-4-naphthalen-1-yl-1,3-thiazol-2-amine
• InChI: InChI=1S/C24H17ClN4OS/c1-30-18-9-10-21-16(12-18)11-17(23(25)27-21)13-26-29-24-28-22(14-31-24)20-8-4-6-15-5-2-3-7-19(15)20/h2-14H,1H3,(H,28,29)/b26-13+
• InChIKey: IKGWZVPDDWNKMS-LGJNPRDNSA-N
• SMILES: COC1=CC2=CC(=C(N=C2C=C1)Cl)C=NNC3=NC(=CS3)C4=CC=CC5=CC=CC=C54

Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production[1].
Antibacterial agent 131 (compound 4m) has antimicrobial activity with MIC90 values of 9.81 μg/mL for Escherichia coli ATCC 35218, E. coli ATCC 25922, Staphylococcus aureus ATCC 6538, and methicillin-resistant S. aureus (MRSA), respectively[1].
Antibacterial agent 131 has anti-candida effect with MIC90 values of ≤0.06, 0.24, 1.95, and 1.95 μg/mL for Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 24433, and C. glabrata ATCC 90030, respectively[1].
Antibacterial agent 131 (24 h) has low cytotoxicity with an IC50 value of 34.51 μM in NIH/3T3 cells[1].
Antibacterial agent 131 (0.06-3.91 μg/mL) inhibits DNA-Gyrase Enzyme against E. coli[1].
Antibacterial agent 131 has antifungal activity via blocking ergosterol production[1].

Reference

[1]. Asaf Evrim Evren, et al. Investigation of Novel Quinoline-Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches. ACS Omega. 2022 Dec 29;8(1):1410-1429.
 [Content Brief]