Anticancer agent 46

• CAT Number: I043697
• CAS Number: 2426686-17-9
• Molecular Formula: C15H14ClN3OS
• Molecular Weight: 319.81
• Purity: ≥95%
• Synonyms: 1-[(E)-1-(5-chloro-2-hydroxyphenyl)ethylideneamino]-3-phenylthiourea
• InChI: InChI=1S/C15H14ClN3OS/c1-10(13-9-11(16)7-8-14(13)20)18-19-15(21)17-12-5-3-2-4-6-12/h2-9,20H,1H3,(H2,17,19,21)/b18-10+
• InChIKey: RULWGWSLXXARKC-VCHYOVAHSA-N
• SMILES: CC(=NNC(=S)NC1=CC=CC=C1)C2=C(C=CC(=C2)Cl)O

Anticancer agent 46 (compound 2) is a potent anticancer agent. Anticancer agent 46 shows antiproliferative activity with an IC50 of 0.986 µM for MGC803 cells. Anticancer agent 46 has the potential for the research of gastric cancer[1].

Reference

[1]. Zhang XH, et al. Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents. Eur J Med Chem. 2020 Aug 1;199:112349.
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