Anticancer agent 93

• CAT Number: I042288
• CAS Number: 94205-22-8
• Molecular Formula: C16H10ClNO4
• Molecular Weight: 315.71
• Purity: ≥95%
• Synonyms: 3-chloro-N-(4-hydroxy-2-oxochromen-3-yl)benzamide
• InChI: InChI=1S/C16H10ClNO4/c17-10-5-3-4-9(8-10)15(20)18-13-14(19)11-6-1-2-7-12(11)22-16(13)21/h1-8,19H,(H,18,20)
• InChIKey: OLUXHDREXNYHFH-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=C(C(=O)O2)NC(=O)C3=CC(=CC=C3)Cl)O

Anticancer agent 93 is a 4-Hydroxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors[1].
Anticancer agent 93 (compound 4h) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~ 50%[1].
Anticancer agent 93 (15 μM; 24-72 h) significantly inhibits A549 cell migration[1].
Anticancer agent 93 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers[1].

Reference

[1]. Zhou R, et, al. Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility. Sci Rep. 2022 Dec 14;12(1):21635.
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