Anticonvulsant agent 2

• CAT Number: I041272
• CAS Number: 75220-84-7
• Molecular Formula: C21H17ClN2
• Molecular Weight: 332.83
• Purity: ≥95%
• Synonyms: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine
• InChI: InChI=1S/C21H17ClN2/c22-17-12-10-16(11-13-17)21-14-20(15-6-2-1-3-7-15)23-18-8-4-5-9-19(18)24-21/h1-13,20,23H,14H2
• InChIKey: HGXLBVMEBUESSS-UHFFFAOYSA-N
• SMILES: C1C(NC2=CC=CC=C2N=C1C3=CC=C(C=C3)Cl)C4=CC=CC=C4

Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity[1].
Anticonvulsant agent 2 (compound10 a; 50 mg/kg, p.o.) decreases locomotor activity with an inhibition rate of 21.01% in rat[1].
Anticonvulsant agent 2 (50 mg/kg; p.o.) shows antiepileptic activity with an inhibition rate of 24.45% in rat[1].

Reference

[1]. Verma R, et al. Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents. Bioorg Chem. 2020 Aug;101:104010.
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