Antifungal agent 48

• CAT Number: I041088
• CAS Number: 2142003-75-4
• Molecular Formula: C13H10O4S
• Molecular Weight: 262.28
• Purity: ≥95%
• Synonyms: 2,3-dihydroxy-6-methyl-5-(thiophene-2-carbonyl)cyclohepta-2,4,6-trien-1-one
• InChI: InChI=1S/C13H10O4S/c1-7-5-9(14)13(17)10(15)6-8(7)12(16)11-3-2-4-18-11/h2-6H,1H3,(H2,14,15,17)
• InChIKey: OJWXHQASZVBEIO-UHFFFAOYSA-N
• SMILES: CC1=CC(=O)C(=C(C=C1C(=O)C2=CC=CS2)O)O

Antifungal agent 48 (Example 308) is an antifungal agent. Antifungal agent 48 is active against Cryptococcus neoformans with a MIC value of 11 μM[1].
Antifungal agent 48 (Example 308) (48 h) shows cytotoxicity with a CC50 of 24 μM in HepDES 19 cells[1].

Reference

[1]. Maureen J. DONLIN, et al. Patent. Anti-fungal compounds. WO2017184752. 2017-10-26.