Antimalarial agent 14

• CAT Number: I043480
• CAS Number: 1150-59-0
• Molecular Formula: C16H10O3
• Molecular Weight: 250.25
• Purity: ≥95%
• Synonyms: 4-hydroxy-3-phenylnaphthalene-1,2-dione
• InChI: InChI=1S/C16H10O3/c17-14-11-8-4-5-9-12(11)15(18)16(19)13(14)10-6-2-1-3-7-10/h1-9,17H
• InChIKey: HCKUADBGJIXWTR-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=C(C3=CC=CC=C3C(=O)C2=O)O

Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent[1].
Antimalarial agent 14 (Compound N3) (0-400 μM, 48 h) inhibits P. falciparum with limited cytotoxicity against human cells[1].
Antimalarial agent 14 inhibits P. falciparum mitochondrial membrane potential with an IC50ΔΨmit of 16 μM[1].

Reference

[1]. Schuck DC, et al. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10;12:234.
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