For research use only. Not for therapeutic Use.
Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.<br />
Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone.
| Catalog Number | M050463 |
| CAS Number | 1397-94-0 |
| Molecular Formula | C₂₈H₄₀N₂O₉(for A1) |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23+,25+/m1/s1 |
| InChIKey | UIFFUZWRFRDZJC-SBOOETFBSA-N |
| SMILES | CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C |
| Reference | The isolation and properties of antimycin A. Bryant R. & Dunshee B.R. et al. J. Am. Chem. Soc. 1949, 71, 2436.<br /> |
