For research use only. Not for therapeutic Use.
Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC50 value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer[1].
Antiproliferative agent-13 (0-10 μM; 72 h) affects proliferation of human A375 melanoma cells[1].
| Catalog Number | I042950 |
| CAS Number | 663214-48-0 |
| Synonyms | 6-amino-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile |
| Molecular Formula | C20H18N2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H18N2O6/c1-23-16-4-10(5-17(24-2)19(16)25-3)18-11-6-14-15(27-9-26-14)7-13(11)28-20(22)12(18)8-21/h4-7,18H,9,22H2,1-3H3 |
| InChIKey | LLTPNRJVRNURSX-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)C2C3=CC4=C(C=C3OC(=C2C#N)N)OCO4 |
| Reference | [1]. Zhang H, et al. Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities. Eur J Med Chem. 2018 Sep 5;157:380-396 |
