For research use only. Not for therapeutic Use.
Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines[1].
Antiproliferative agent-15 (compound 6a) shows antiproliferative activity against human colon (HCT116 and HCT15), brain (LN-229 and GBM-10) cancer cell lines, with IC50 values of 8.3 μM, 4.8 μM, 18.3 μM, and 12 μM, respectively. However, Antiproliferative agent-15 has no active against ovarian (A2780) cancer cell lines and normal cell line (CHO)[1].
| Catalog Number | I042513 |
| CAS Number | 19819-18-2 |
| Synonyms | 2-phenyl-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-4-one |
| Molecular Formula | C16H14N2OS |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14N2OS/c19-15-13-11-8-4-5-9-12(11)20-16(13)18-14(17-15)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H,17,18,19) |
| InChIKey | CDFWRIZOSNAGCV-UHFFFAOYSA-N |
| SMILES | C1CCC2=C(C1)C3=C(S2)N=C(NC3=O)C4=CC=CC=C4 |
| Reference | [1]. Haneen Amawi, et al. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. Eur J Med Chem. 2017 Sep 29;138:1053-1065. |
