Antiproliferative agent-16

• CAT Number: I042469
• CAS Number: 15641-17-5
• Molecular Formula: C17H15N3O
• Molecular Weight: 277.32
• Purity: ≥95%
• Synonyms: N-[(E)-1H-indol-3-ylmethylideneamino]-2-phenylacetamide
• InChI: InChI=1S/C17H15N3O/c21-17(10-13-6-2-1-3-7-13)20-19-12-14-11-18-16-9-5-4-8-15(14)16/h1-9,11-12,18H,10H2,(H,20,21)/b19-12+
• InChIKey: VDNPCDIEIGAGRI-XDHOZWIPSA-N
• SMILES: C1=CC=C(C=C1)CC(=O)NN=CC2=CNC3=CC=CC=C32

Antiproliferative agent-16 is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells)[1].
Antiproliferative agent-16 (compound 18f) shows cytotoxicity against DU145, LnCaP, MDA-MB231, MCF7, and PaCa2 cancer cells, with IC50 values of 115.1 μM, 51.63 μM, 300.8 μM, 6.94 μM, and 91.18 μM, respectively[1].

Reference

[1]. Swapna Sundaree, et al. Synthesis and anticancer activity study of indolyl hydrazide-hydrazones. Med Chem Res 25, 941-950 (2016).