Antiproliferative agent-37

• CAT Number: I040570
• CAS Number: 2989275-31-0
• Molecular Formula: C21H17FN2O2
• Molecular Weight: 348.37
• Purity: ≥95%
• Synonyms: 7-(2,4-dimethoxyphenyl)-3-(3-fluorophenyl)-1H-pyrrolo[2,3-c]pyridine
• InChI: InChI=1S/C21H17FN2O2/c1-25-15-6-7-17(19(11-15)26-2)21-20-16(8-9-23-21)18(12-24-20)13-4-3-5-14(22)10-13/h3-12,24H,1-2H3
• InChIKey: GFGUONALQQRUOT-UHFFFAOYSA-N
• SMILES: COC1=CC(=C(C=C1)C2=NC=CC3=C2NC=C3C4=CC(=CC=C4)F)OC

Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle[1].
Antiproliferative agent-37 (compound 10J) shows cytotoxic/cytostatic effect against A431, HT1080, MCF-7, MDA-MB-231, and AG01523 cell strains, with IC50 values of 0.013±0.004, 0.014±0.008, 0.14±0.04, 0.018±0.009, 56.3±4.3 μM, respectively[1].

Reference

[1]. Lougiakis N, et al. Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles. Eur J Med Chem. 2023 Sep 13;261:115804.
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