Antitrypanosomal agent 1

• CAT Number: I015082
• CAS Number: 75144-12-6
• Molecular Formula: C₁₁H₁₄Cl₃NO
• Molecular Weight: 282.59
• Purity: ≥95%
• Target: Parasite
• Storage: 2-8°C
• IUPAC Name: 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one;hydrochloride
• InChI: InChI=1S/C11H13Cl2NO.ClH/c1-14(2)6-5-11(15)8-3-4-9(12)10(13)7-8;/h3-4,7H,5-6H2,1-2H3;1H
• InChIKey: PRRKQCKNKRZOPV-UHFFFAOYSA-N
• SMILES: CN(C)CCC(=O)C1=CC(=C(C=C1)Cl)Cl.Cl

Antitrypanosomal agent 1（Cat No.:I015082）is a potent and selective inhibitor of trypanothione reductase (TR), an enzyme crucial for the survival of Trypanosoma parasites. It exhibits an IC₅₀ of 3.3 μM against TR and an EC₅₀ of 1 μM against T. brucei, the causative agent of African sleeping sickness.By inhibiting TR, this agent disrupts the parasite’s redox balance, leading to oxidative stress and cell death. Its selectivity over human glutathione reductase (IC₅₀ = 64.8 μM) suggests a favorable safety profile, making it a promising candidate for developing new treatments for trypanosomiasis.

Reference

[1]. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.