Antitrypanosomal agent 9

• CAT Number: I042522
• CAS Number: 438474-67-0
• Molecular Formula: C22H27NO3
• Molecular Weight: 353.45
• Purity: ≥95%
• Synonyms: [4-[(4-ethoxyphenoxy)methyl]phenyl]-(3-methylpiperidin-1-yl)methanone
• InChI: InChI=1S/C22H27NO3/c1-3-25-20-10-12-21(13-11-20)26-16-18-6-8-19(9-7-18)22(24)23-14-4-5-17(2)15-23/h6-13,17H,3-5,14-16H2,1-2H3
• InChIKey: WFMWFIJMQIVRKV-UHFFFAOYSA-N
• SMILES: CCOC1=CC=C(C=C1)OCC2=CC=C(C=C2)C(=O)N3CCCC(C3)C

Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].
Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1].
Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].

Reference

[1]. Manos-Turvey Alexandra, et al. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. Med Chem Commun. 2015, 6(3), 403–406.