Antitumor agent-119

• CAT Number: I040674
• CAS Number: 913169-79-6
• Molecular Formula: C18H14N4O
• Molecular Weight: 302.33
• Purity: ≥95%
• Synonyms: N-[(E)-1-isoquinolin-3-ylethylideneamino]-1,3-benzoxazol-2-amine
• InChI: InChI=1S/C18H14N4O/c1-12(16-10-13-6-2-3-7-14(13)11-19-16)21-22-18-20-15-8-4-5-9-17(15)23-18/h2-11H,1H3,(H,20,22)/b21-12+
• InChIKey: CQYWNLWTQUEJRG-CIAFOILYSA-N
• SMILES: CC(=NNC1=NC2=CC=CC=C2O1)C3=CC4=CC=CC=C4C=N3

Antitumor agent-119 (compound 13K) is a 2-benzoxazolyl hydrazone derivative with anticancer activities. Antitumor agent-119 inhibits the cell growth of Butkitt, CCRF-CEM, HeLa, and HT-29 with IC50 values of 30 nM, 140 nM, 100 nM, and 40 nM, respectively[1].

Reference

[1]. N. S. Hari Narayana Moorthy, et al. QSAR analysis of 2-benzoxazolyl hydrazone derivatives for anticancer activity and its possible target prediction. Med Chem Res 21, 133–144 (2012).