Antiviral agent 24

• CAT Number: I042458
• CAS Number: 23661-03-2
• Molecular Formula: C18H18F3N5O4
• Molecular Weight: 425.36
• Purity: ≥95%
• Synonyms: (2R,4S,5R)-2-(hydroxymethyl)-5-[6-[[3-(trifluoromethyl)phenyl]methylamino]purin-9-yl]oxolane-3,4-diol
• InChI: InChI=1S/C18H18F3N5O4/c19-18(20,21)10-3-1-2-9(4-10)5-22-15-12-16(24-7-23-15)26(8-25-12)17-14(29)13(28)11(6-27)30-17/h1-4,7-8,11,13-14,17,27-29H,5-6H2,(H,22,23,24)/t11-,13?,14+,17-/m1/s1
• InChIKey: SDQKDCSBWUSBDO-OVHGWZCWSA-N
• SMILES: C1=CC(=CC(=C1)C(F)(F)F)CNC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O

Antiviral agent 24 is a potent antiviral agent with EC50 values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner[1].
Antiviral agent 24 (compound 25) (0-1000 µM) inhibits METTL3/METTL14 complex activity with an EC50 value of 129 µM[1].

Reference

[1]. Salerno M, et al. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. Eur J Med Chem. 2022 Nov 24;246:114942.
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