Antofine

• CAT Number: I012824
• CAS Number: 32671-82-2
• Molecular Formula: C23H25NO3
• Molecular Weight: 363.457
• Purity: ≥95%
• Synonyms: (-)-Antofine; (R)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2b]isoquinoline; 2,3,6-trimethoxy-9,10,11,12,12a,13-hexahydro-9a-aza-cyclopenta[b]triphenylene; (R)-antofine; R-antofine
• Target: Plants
• IUPAC Name: (13aR)-2,3,6-trimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine
• InChI: InChI=1S/C23H25NO3/c1-25-15-6-7-16-18(10-15)20-12-23(27-3)22(26-2)11-19(20)17-9-14-5-4-8-24(14)13-21(16)17/h6-7,10-12,14H,4-5,8-9,13H2,1-3H3/t14-/m1/s1
• InChIKey: NCVWJDISIZHFQS-CQSZACIVSA-N
• SMILES: COC1=CC2=C(C=C1)C3=C(CC4CCCN4C3)C5=CC(=C(C=C52)OC)OC

Antofine is a naturally occurring alkaloid primarily found in certain plant species, particularly within the Apocynaceae and Asclepiadaceae families. It is recognized for its potent biological activities, including cytotoxic, antiviral, and antifungal properties. Antofine’s chemical structure features a phenanthroindolizidine framework, which is responsible for its ability to interact with various cellular targets, making it a subject of interest in cancer research and drug development. Due to its cytotoxic effects, Antofine is being explored for its potential use in developing anticancer therapies. However, its high toxicity also necessitates careful handling and further studies to optimize its therapeutic applications while minimizing side effects.